Selected Publications
Single-cell mapping of regulatory DNA:Protein interactions.
Chi WY, Yoon SH, Mekerishvili L, Ganesan S, Potenski C, Izzo F, Landau D, Raimondi I.bioRxiv [Preprint]. 2025 Jan 2:2024.12.31.630903. doi: 10.1101/2024.12.31.630903.
Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells
Izzo F*#, Myers RM*, Ganesan S*, Mekerishvili L*, Kottapalli S, Prieto T, Eton EO, Botella T, Dunbar AJ, Bowman RL, Sotelo J, Potenski C, Mimitou EP, Stahl M, El Ghaity-Beckley S, Arandela J, Raviram R, Choi DC, Hoffman R, Chaligné R, Abdel-Wahab O, Smibert P, Ghobrial IM, Scandura JM, Marcellino B, Levine RL, Landau DA#. Nature. 2024 May;629(8014):1149-1157. doi: 10.1038/s41586-024-07388-y. Epub 2024 May 8.PMID: 38720070
* co-first authors; #co-corresponding authors.
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.
Nam AS*, Dusaj N*, Izzo F*, Murali R*, Myers RM*, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Gaiti F, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DA. Nat Genet. 2022 Oct;54(10):1514-1526.
doi: 10.1038/s41588-022-01179-9. Epub 2022 Sep 22.PMID: 36138229
* co-first authors
DNA methylation disruption reshapes the hematopoietic differentiation landscape.
Izzo F*, Lee SC*, , Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA. Nat Genet. 2020 Apr;52(4):378-387. doi: 10.1038/s41588-020-0595-4. Epub 2020 Mar 23.PMID: 32203468
* co-first authors
Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.
Wesely J, Kotini AG, Izzo F, Luo H, Yuan H, Sun J, Georgomanoli M, Zviran A, Deslauriers AG, Dusaj N, Nimer SD, Leslie C, Landau DA, Kharas MG, Papapetrou EP. Cell Rep. 2020 Jun 2;31(9):107688. doi: 10.1016/j.celrep.2020.107688.PMID: 32492433
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
Cheng Y*, Luo H*, Izzo F*, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG. Cell Rep. 2019 Aug 13;28(7):1703-1716.e6. doi: 10.1016/j.celrep.2019.07.032.PMID: 31412241
* co-first authors
Somatic mutations and cell identity linked by Genotyping of Transcriptomes.
Nam AS, Kim KT, Chaligne R, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P, Landau DA. Nature. 2019 Jul;571(7765):355-360. doi: 10.1038/s41586-019-1367-0. Epub 2019 Jul 3.PMID: 31270458
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation.
Lhoumaud P, Sethia G, Izzo F, Sakellaropoulos T, Snetkova V, Vidal S, Badri S, Cornwell M, Di Giammartino DC, Kim KT, Apostolou E, Stadtfeld M, Landau DA, Skok J. Genome Biol. 2019 Nov 21;20(1):248. doi: 10.1186/s13059-019-1853-6.PMID: 31752933
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction.
Gómez-Salinero JM*, Izzo F*, Lin Y, Houghton S, Itkin T, Geng F, Bram Y, Adelson RP, Lu TM, Inghirami G, Xiang JZ, Lis R, Redmond D, Schreiner R, Rabbany SY, Landau DA, Schwartz RE, Rafii S. Cell Stem Cell. 2022 Apr 7;29(4):593-609.e7. doi: 10.1016/j.stem.2022.03.002. Epub 2022 Mar 31.PMID: 35364013
* co-first authors
Reviews, Commentaries & Blogs
The crossroads of clonal evolution, differentiation hierarchy and ontogeny in leukemia development.
Sturgeon CM, Wagenblast E, Izzo F, Papapetrou EP. Blood Cancer Discov. 2024 Dec 9. doi: 10.1158/2643-3230.BCD-24-0235. Online ahead of print.PMID: 39652739
A BAX door to venetoclax resistance.
Izzo F, Landau DA. Blood. 2022 Feb 24;139(8):1124-1126. doi: 10.1182/blood.2021013788.PMID: 35201333
Disruption of DNA methylation reshapes the hematopoietic differentiation landscape.
Commentary published in Springer Nature Research Communities about how TET2 and DNMT3A mutations reashape the differentiation landscape in hematopoiesis.
Genetic and epigenetic determinants of B-cell lymphoma evolution.
Izzo F, Landau DA. Curr Opin Hematol. 2016 Jul;23(4):392-401. doi: 10.1097/MOH.0000000000000258.PMID: 27135978
Collaborations
Natural killer cells' functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes.
Rodriguez-Sevilla JJ, Ganan-Gomez I, Kumar B, Thongon N, Ma F, Chien KS, Kim YJ, Yang H, Loghavi S, Tan R, Adema V, Li Z, Tanaka T, Uryu H, Kanagal-Shamanna R, Al-Atrash G, Bejar R, Banerjee PP, Lynn Cha S, Montalban-Bravo G, Dougherty M, Fernandez Laurita MC, Wheeler N, Jia B, Papapetrou EP, Izzo F, Dueñas DE, McAllen S, Gu Y, Todisco G, Ficara F, Della Porta MG, Jain A, Takahashi K, Clise-Dwyer K, Halene S, Bertilaccio MTS, Garcia-Manero G, Daher M, Colla S. Nat Commun. 2025 Apr 11;16(1):3450. doi: 10.1038/s41467-025-58662-0.PMID: 40216768
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response.
Scourzic L, Izzo F, Teater M, Polyzos AP, Cucereavii L, Chin CR, Papin A, Pinto HB, Mlynarczyk C, Tsialta I, Xia M, Lidoski A, Myers RM, Israel EM, Venturutti L, Mackay SP, Hoehn KB, Skoultchi AI, Béguelin W, Stadtfeld M, Chen Z, Landau DA, Melnick AM, Apostolou E. Nat Cell Biol. 2026 Jan;28(1):35-48. doi: 10.1038/s41556-025-01833-4. Epub 2025 Dec 29.PMID: 41466145
Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.
Wang K, Saniei S, Poddar N, Martinez IG, Chao C, Autar S, Fiore P, Carcamo S, Sreenath M, Peplinski JH, Ries RE, Mei AH, Rahman NA, Mekerishvili L, Quijada-Álamo M, Freed G, Zhang M, Lachman K, Diaz Z, Gonzalez MM, Zhang J, Pham G, Filipescu D, Berisa M, Balestra T, Wheeler N, Reisz JA, D'Alessandro A, Puleston DJ, Bernstein E, Chipuk JE, Wunderlich M, Tasian SK, Marcellino BK, Glass IA; BDRL; Sturgeon CM, Landau DA, Chen Z, Papapetrou EP, Izzo F, Meshinchi S, Hasson D, Wagenblast E; BDRL. Cancer Discov. 2025 Dec 6:OF1-OF30. doi: 10.1158/2159-8290.CD-25-0556. Online ahead of print.PMID: 41351880